Pamer Lab

Welcome to the Eric Pamer Laboratory

 
Humans and other mammals are colonized by complex populations of microbes that constitute the microbiota.  Some commensal bacteria enhance immune defenses by inducing host expression of antimicrobial factors while others secrete antimicrobial molecules that inhibit pathogens.  The Eric Pamer laboratory studies interactions between pathogenic and beneficial bacteria and their mammalian hosts.  Our laboratory’s research focuses on a wide range of commensal bacteria that have been characterized at the genomic, proteomic and metabolomic level and we are using gnotobiotic mice to test assembled commensal consortia for their ability to enhance resistance against pathogenic bacteria.  Using these platforms, we have identified multiple novel mechanisms of antimicrobial resistance that can be exploited to reduce the risk of infection by highly antibiotic-resistant pathogens.

Welcome to the Pamer Laboratory

Welcome to the Pamer Laboratory

Recent Original Publications

Kim SG, Becattini S, Moody TM, Shliaha PV, Littmann ER, Seok R, Gjonbalaj M, Eaton V, Fontana E, Amoretti L, Wright R, Caballero S, Wang Z-MX, Jung H-J, Morjaria SM, Leiner IM, Qin W, Ramos RJJF, Cross JR, Narushima S, Hon da K, Peled JU, Hendrickson RC, Taur Y, van den Brink MRM, Pamer EG. Microbiota-derived lantibiotic restores resistance against vancomycin-resistant Enterococcus.  Nature. 2019; Aug;572(7771):665-669.

Caballero S, Kim S, Carter RA, Leiner IM, Sušac B, Miller L, Kim GJ, Ling L, Pamer EG. Cooperating Commensals Restore Colonization Resistance to Vancomycin-Resistant Enterococcus faecium. Cell Host Microbe. 2017; 21(5):592-602.

Xiong H, Keith JW, Samilo DW, Carter RA, Leiner IM, Pamer EG. Innate Lymphocyte/Ly6C(hi) Monocyte Crosstalk Promotes Klebsiella pneumoniae Clearance. Cell. 2016; 165(3):679-89.

Buffie CG, Bucci V, Stein RR, McKenney PT, Ling L, Gobourne A, No D, Liu H, Kinnebrew M, Viale A, Littmann E, van den Brink MR, Jenq RR, Taur Y, Sander C, Cross J, Toussaint NC, Xavier JB, Pamer EG. Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile. Nature. 2014; 517:205-8.

Review Articles

Keith JW, Pamer EG. Enlisting commensal microbes to resist antibiotic- resistant pathogens. Journal of Experimental Medicine. 2019; 216(1):10-19.

Sorbara MT, Pamer EG. Interbacterial mechanisms of colonization resistance and the strategies pathogens use to overcome them. Mucosal Immunology. 2019:12(1):1-9.

Pamer EG. Resurrecting the intestinal microbiota to combat antibiotic-resistant pathogens. Science.  2016; 352(6285):535-8.

Kim S, Covington A, Pamer EG.  The Intestinal Microbiota: Antibiotics, Colonization Resistance, and Enteric Pathogens.  Immunological Reviews. 2017; 279(1):90-105.

Lewis BB, Pamer EG. Microbiota Therapy for Clostridium difficile and Antibiotic Resistant Enteric Infections. Annual Reviews of Microbiology. 2017; 71:157-178.

Pamer EG. Resurrecting the intestinal microbiota to combat antibiotic-resistant pathogens. Science.  2016; 352(6285):535-8.

Abt MC, McKenney PT, Pamer EG. Clostridium difficile colitis: pathogenesis and host defense. Nature Reviews Microbiology. 2016; 14(10):609-20.

Current Research